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GSK598809 hydrochloride
CAS No. 863680-44-8
GSK598809 hydrochloride( GSK 598809 | GSK-598809 )
Catalog No. M16254 CAS No. 863680-44-8
GSK598809 hydrochloride is a potent, selective, CNS penetrant and orally bioavailable dopamine D3 receptor antagonist with pKi of 8.9; displays >100-fold selectivity over D2 and H1 receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameGSK598809 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionGSK598809 hydrochloride is a potent, selective, CNS penetrant and orally bioavailable dopamine D3 receptor antagonist with pKi of 8.9; displays >100-fold selectivity over D2 and H1 receptors.
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DescriptionGSK598809 hydrochloride is a potent, selective, CNS penetrant and orally bioavailable dopamine D3 receptor antagonist with pKi of 8.9; displays >100-fold selectivity over D2 and H1 receptors; significantly attenuates the expression of conditioned place preference (CPP) to nicotine and cocaine; potentiates the hemodynamic effects of cocaine in dogs, also increases mean arterial blood pressure and heart rate in vivo.Other Indication Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsGSK 598809 | GSK-598809
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorDopamine Receptor
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Research AreaOther Indications
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IndicationOther Disease
Chemical Information
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CAS Number863680-44-8
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Formula Weight517.972
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Molecular FormulaC22H24ClF4N5OS
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name5-(5-((3-(1-(2-fluoro-4-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]hexan-3-yl)propyl)thio)-4-methyl-4H-1,2,4-triazol-3-yl)-4-methyloxazole hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Micheli F, et al. J Med Chem. 2010 Jan 14;53(1):374-91.
2. Appel NM, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):484-92.
3. Dodds CM, et al. Appetite. 2012 Aug;59(1):27-33.
4. Searle G, et al. Biol Psychiatry. 2010 Aug 15;68(4):392-9.
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